澳门十大正规平台网站

李冬梅

文章来源:澳门十大正规平台网站 发布时候: 2017-12-25阅读次数: 6877

博士研讨生导师简介

姓名

李冬梅

研讨标的目的

  • 环境净化与安康

  • 泌尿生殖系肿瘤产生的机制研讨

接洽体例

Email: lidm@doremond.com

学术兼职:

中国剖解学会会员

江苏省剖解学会第十二届理事会构造胚胎学专业委员会委员

江苏省免疫学会转化医学专业委员会委员

《中华男科学》杂志编委

环境毒理类SCI杂志审稿专家

小我简介

教导和任务履历:

19976月 获南京医科大学临床医学学士学位

20076月 获南京大学理学博士学位

201311月—201411月,美国国立卫生院肿瘤研讨中间 访学学者

20078至今 澳门十大正规平台网站 讲师、副传授,博士生导师

讲授:

南京大学“百”条理优良课程《构造学和胚胎学》主讲教员、学校公选课《人类生殖》主讲教员;

《构造病理学》、《疾病研讨的生物学体例》和《生殖生物学》等研讨生课程主讲教员

代表性论文[5年通信作者和第一作者]

  1.  Tan Ma, Yuan Zhou, Yunhui Xia, Xiannan Meng, Haibo Jin, Bo Wang, Yusheng Chen, Jiayin Qiu, Jiang Wu, Jie Ding, Xiaodong Han, Dongmei Li*. Maternal Exposure to Di- n-butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE 2/MMP-2 in Mouse Offspring. Environ Sci Technol. 2020 Jul 7;54(13):8245-8258.

  2.  Tan Ma, Jiwei Hou, Yuan Zhou, Yusheng Chen, Jiayin Qiu, Jiang Wu, Jie Ding, Xiaodong Han, Dongmei Li*. Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2. Environ Health. 2020 Aug 1;19(1):87.

  3.  Xiannan Meng, Ling Zhang, Jiwei Hou, Tan Ma, Chun Pan, Yuan Zhou, Ruitong Han, Yuanzhen Ding, Haoran Peng, Zou Xiang, Dongmei Li*, Xiaodong Han*. The Mechanisms in the Altered Ontogenetic Development and Lung-Related Pathology in Microcystin-Leucine Arginine (MC-LR)-paternal-exposed Offspring Mice. Sci Total Environ. 2020 Sep 20;736:139678.

  4. Yunhui Xia, Tan Ma, Jie Ji, Liupan Zhang, Yu Wang, Jiang Wu, Jie Ding, Xiaodong Han*, Dongmei Li*. In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice. Ecotoxicol Environ Saf. 2020 May 7;198:110698.

  5.  Ling Zhang, Xiannan Meng, Chun Pan, Feng Qu, Weidong Gan, Zou Xiang, Xiaodong Han*, Dongmei Li*. piR-31470 epigenetically suppresses the expression of glutathione S-transferase pi 1 in prostate cancer via DNA methylation. Cell Signal. 2020 Mar; 67:109501.

  6.  Yuan Zhou, Tan Ma, Minghao Yan, Xiannan Meng, Jiang Wu, Jie Ding, Xiaodong Han*, Dongmei Li*. Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes.Sci Total Environ. 2020 Mar 10;707:136139.

  7.  Yabing Chen, Jing Wang, Dihui Xu, Zou Xiang, Jie Ding, Xiaoyu Yang, Dongmei Li*, Xiaodong Han*. M6A mRNA Methylation Regulates Testosterone Synthesis Through Modulating Autophagy in Leydig Cells. Autophagy. 2020 Jan 31;1-19.

  8.  Ruitong Han, Ling Zhang, Weidong Gan, Kai Fu, Ke Jiang, Jie Ding, Jiang Wu, Xiaodong Han*, Dongmei Li*.piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine. Prostate. 2019 Mar 22. 79: 798-812.

  9.  Yin X, Wang B, Gan W, Zhuang W, Xiang Z, Han X*, Li D*. TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. J Exp Clin Canc Res, 2019, Mar 8, 38(1): 119.

  10.  Ning Liu, Weidong Gan, Feng Qu, Zhen Wang, Wenyuan Zhuang, Sezim Agizamhan, Linfeng Xu, Juanjuan Yin,Hongqian Guo, and Dongmei Li*. Does the Fuhrman or World Health Organization/International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation Renal Cell Carcinoma?A 10-Year Single-Center Study. Am J Pathol. 2018 Apr;188(4):929-936.

  11.  Ling Zhang, Xiannan Meng, Zou Xiang, Dongmei Li*, Xiaodong Han*. Roles of mmu_piR_003399 in microcystin-leucine arginine (MC-LR)-induced reproductive toxicity in the spermatogonial cells and testis. Toxicological Sciences, 2018 Jan 1;161(1), 2018, 159–170.

  12.  Xiaoqin Yin, Tan Ma, Ruitong Han, Jie Ding, Huan Zhang(*), Han Xiaodong(*), Li DongMei*, MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)–induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018 Mar;47:79-88.

  13.  Chen Yabing, Wang Jing, Pan Chun, Li Dongmei*, Han Xiaodong*. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, Cell. Mol. Life Sci. 2018 Mar; 75:1117–1132.

  14.  Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han and Dongmei Li*. Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. International Journal of Environmental Research and Public Health. 2017, Oct 24;14, 1284.

  15.  Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan*, Dongmei Li*, Hongqian Guo. PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. PLoS ONE2017 Sep 26; 12(9): e0185337.

  16.  Zhang Ling, Zhang Hui, Zhang Huan, Benson Mikael, Han Xiaodong, Li Dongmei*. Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Food Chem Toxicol. 2017 Apr 13;105:177-185.

  17.  Hui Zhang, LihuiWang, SongShen, Chenchen Wang, Zou Xiang, Xiaodong Han*, Dongmei Li*. Toxic effects of microcystin-LR on the development of prostate in mice.Toxicology. 2017 Apr 1;380:50-61.

  18.  Yabing Chen, Yuan Zhou, Jing Wang, Lihui Wang, Xiang Zou, Dongmei Li*, and Xiaodong Han*. Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice. Sci Rep. 2016 Dec 15;6:39238.

  19.  Ning Liu, Zhen Wang, Weidong Gan*, Lei Xiong, Baolei Miao, Xiancheng Chen, Hongqian Guo, Dongmei Li*. Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusions: Clinical Features, Treatments and Prognosis. PLoS One. 2016 Nov 28;11(11):e0166897.

  20.  Xiannan Meng , Ling Zhang, Xiang Chen, Zou Xiang, Dongmei Li*, and Xiaodong Han*. miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice. Toxins (Basel). 2016 Sep 6;8(9). pii: E260.

  21. Ruoyu Wang, Xiaoqin Yin, Hui Zhang, JiweiWang, Lin Chen, Jingwen Chen, Xiaodong Han, Zou Xiang, and Dongmei Li*. Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells. J Immunol Res. 2016; 2016:8439594.

承当科研名目[名目担任人]

  1. 增塑剂邻苯二甲酸二丁酯胚胎期裸露引发雄性小鼠芳华期提早的份子机制研讨 国度天然科学基金(31971517

  2. miR-7a抒发上调在邻苯二甲酸二丁酯(DBP)搅扰芳华期前睾丸撑持细胞增殖中的机制研讨 国度天然科学基金(21377052

  3. 水体典范环境内排泄搅扰物结合感化雄性生殖功效影响的机制研讨国度天然科学基金(30800115

  4. miR-7的抒发下调在前线腺癌产生中的机制研讨江苏省天然科学基金(BK20131281

  5. 雌激素受体β亚型(ER-β)基因多态性与前线腺癌易感的相干性研讨江苏省天然科学基金(BK2010367

  6. ER-β基因启动子区甲基化程度与前线腺癌易感的相干性研讨江苏省第八批“六大人材岑岭”高条理人材培育工具名目(卫生行业2011-WS070

  7. 水体典范环境内排泄搅扰物结合感化雄性生殖功效影响的机制研讨 教导部新青年教员基金(200802841006

  8. 肿瘤按捺基因雌激素受体β亚型(ER-β)的抒发变更在前线腺癌细胞旌旗灯号收集中的感化阐发 吴阶平基金会(320.6752.1219

  9. Xp11.2易位型肾癌份子诊断模子的成立 性命阐发化学国度重点尝试室自立研讨课题(5431ZZXM2004

  10. miR-7的抒发下调在前线腺癌产生中的机制研讨 性命阐发化学国度重点尝试室开放研讨基金

  11. 利用星形金纳米探针对肺干细胞分解机制的研讨生物电子学国度重点尝试室开放研讨基金(G5

  12. miR-7a抒发上调在邻苯二甲酸二丁酯(DBP)搅扰芳华期前睾丸撑持细胞增殖中的机制研讨 中心高校根基科研营业费立项名目(020620130656

  13. GPR30介导外源性雌激素搅扰精原细胞微环境促精原干细胞非常增殖的感化机制研讨中心高校根基科研营业费

  14. GPR30介导雌激素和外源性雌激素影响大鼠血睾樊篱的比拟研讨中心高校根基科研营业费专项资金(新世纪优异人材培育打算)(1095021440

  15. 水体中典范环境内排泄搅扰物结合感化雄性生殖功效影响的机制研讨 中心高校根基科研营业费苗圃名目(1117021401

  16. 雌激素受体β亚型(ER-β)基因多态性与前线腺癌易感的相干性研讨 中心高校根基科研营业费自在摸索名目(1118021402


获奖环境

2020年 南京大学“魅力导师奖”

2019年 江苏省高校微课讲授比赛 三等奖

2018年 江苏省教导讲授与研讨功效奖(研讨类)三等奖

2018年 南京大学“魅力导师奖”

2017年 华东地域青年学者岑岭论坛青年学者奖

2017年 南京大学讲授功效奖

2016年 南京大学立异育人奖

2015年 澳门十大正规平台网站 优异教员



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