澳门十大正规平台网站

姓名

韩晓冬

研讨标的目的

1生殖与发育

2干细胞与构造再生

接洽体例

德律风: 025-83686497

Email: hanxd@doremond.com

学术兼职:

教导部高档学校根本医学类专业讲授指点委员会委员

江苏省高档学校医药教导研讨会副理事长

江苏省剖解学会理事长

《中华男科学杂志》 编委

小我简介

澳门十大正规平台网站 党委布告，博士，构造胚胎学传授，博士生导师。1984年毕业于南京大先生物系，获学士学位；1987年于南京大先生物系获硕士学位；2004年于南京大先性命科学院获博士学位。2001年，作为高档拜候学者赴美国哈佛大学澳门十大正规平台网站 Beth Israel Deaconess Medical Center展开协作研讨。持久从事生殖与发育、干细胞与构造再生研讨，掌管并到场国度天然科学基金、国度“973打算”、教导部博士点基金、江苏省天然科学基金等研讨名目，在国际外学术刊物共颁发论文180余篇。参编《构造胚胎学》、《生殖病理学》课本，主讲的“构造胚胎学”当选南京大学百门优良课程建设。

代表性论文

1. Jin Haibo, Ma Tan, Sha Xiaoxuan, Liu Zhengyu, Zhou Yuan, Meng Xiannan, Chen Yabing, 韩晓冬*, Die Jie*. Polystyrene microplastics induced male reproductive toxicity in mice. Journal of Hazardous Materials, 401 (2021): 123430.

2. Chen Yabing, Wang Jing, Xu Dihui, Xiang Zou, Ding Jie, Yang Xiaoyu, Li Dongmei*, 韩晓冬*. m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy, 2020 Jan 31:1-19. doi: 10.1080/15548627.2020.1720431.

3. Wang Jing, Chen Yabing, Zhang Changliang, Xiang Zou, Ding Jie*, 韩晓冬*. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of Hazardous Materials, 2019, 373: 504–518.

4. Wang Jing, Zhang Changliang, Zhu Jinling, Ding Jie, Chen Yabing*, 韩晓冬*. Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR. Science of the Total Environment, 2019, 689: 662–678.

5. Meng Xiannan, Peng Haoran, Ding Yuanzhen, Zhang Ling, Yang Jingping*, 韩晓冬*. A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity. Science of the Total Environment, 2019, 667: 563–577.

6. Zhang Changliang, Wang Jing, Zhu Jinling, Chen Yabing*,韩晓冬*. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. Science of The Total Environment . 2019 Nov 1:134702. doi: 10.1016/j.scitotenv.2019.134702.

7. Jin Haibo, Wang Bo, Hou Jiwei, MaTan, Qiao Dan, MiaoYingwen, Ding Jie*, 韩晓冬*. The mechanism of Oatp1a5-mediated microcystin-leucine arginine entering into GnRH neurons. Ecotoxicology and Environmental Safety, 2019, 184:109614.

8. Wang Jing, Chen Yabing, Chen Zhangpeng, Xiang Zou, Ding Jie*, and 韩晓冬*. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus. Ecotoxicology and Environmental Safety. 2018, 163:391–399.

9. Chen Yabing, Wang Jing, Chen Xiang, Li Dongmei, 韩晓冬*. Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels. Aquatic Toxicology. 2018, 199:116-126.

10. Ding Jie, Wang Jing, Jin Haibo, Xia Tianjiao, Chen Yi, Wu Jiang, and 韩晓冬*. Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice. Science of the Total Environment，2018, 643:496–506.

11. Pan Chun, Chen Yabing, Xu Tianchi, Wang Jing, Li Dongmei, and 韩晓冬*. Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia. Environmental Pollution. 2018, 242: 1535-1545.

12. Hou Jiwei, Ma Tan, Cao Honghui, Chen Yabing, Wang Cong, Chen Xiang, Xiang Zou, and 韩晓冬*. TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis. Journal of Cellular Physiology. 2018,233(3):2409-2419.

13. Zhang Ling, Meng Xiannan, Xiang Zou, Li Dongmei*, and韩晓冬*. Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis. Toxicological sciences, 2018,161(1):159–170.

14. Hou Jiwei, Shi Jingyan, Chen Ling, Lv Zhongyang, Chen Xiang, Cao Honghui, Xiang Zou, and 韩晓冬*. M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling. 2018 ,16:89.

15. Chen Xiang, Shi Chaowen, Cao Honghui, Chen Ling, Hou Jiwei, Xiang Zou, Hu Kebin, and 韩晓冬*. The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death Disease. 2018,9:639.

16. Chen Yabing, Wang Jing, Pan Chun, Li Dongmei*, 韩晓冬*. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, 2018, 75 (6):1117-1132.

17. Chen Yabing, Wang Jing, Zhang Qin, Xiang Zou, Li Dongmei, 韩晓冬*. Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. Environmental Pollution 2017, 229:964-975.

18. Ding Jie, Wang Jing, Xiang Zou, Diao Weiyi, Su Moxi, Shi Weiwei, Wan Ting, 韩晓冬*. The Organic anion transporting polypeptide 1a5 is a pivotal transporter for the uptake of microcystin-LR by gonadotropin-releasing hormone neurons. Aquatic Toxicology. 2017,182:1-10.

19. Shi Chaowen, Cao Xiaowei, Chen Xiang, Sun Zhaorui, Xiang Zou, Zhao Hang, Qian Weiping*, 韩晓冬*. Intracellular surface-enhanced Raman scattering probes based on TAT peptide-conjugated Au nanostars for distinguishing the differentiation of lung resident mesenchymal stem cells. Biomaterials, 2015 Jul; 58: 10-25.

20. Zhou Yuan, Zou Xiang, Dongmei Li*, 韩晓冬*. Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014, 48: 6383-6390.

承当科研名目[名目担任人]

1.国度天然科学基金名目（31870492）: 微囊藻毒素持久低剂量裸露引发小鼠进修影象才能消退的份子机制切磋

2.国度天然科学基金名目（81570059）: Hedgehog-Wnt旌旗灯号通路到场特发性肺纤维化病发的份子机制切磋及疾病干涉干与的根本研讨

3.国度天然科学基金名目（31370524）: 微囊藻毒素下调雄性大鼠雄激素（睾酮)分化和排泄的机制研讨

4.国度天然科学基金名目（30970530）: 微囊藻毒素低剂量长时候裸露对雄性大鼠生殖体系的影响及其机制研讨

5.国度天然科学基金名目（81170054）: 调控Wnt旌旗灯号通路对特发性肺纤维化产生成长影响的研讨

6.国度天然科学基金名目（20577019）: 环境内排泄搅扰物烷基酚生殖毒性危险评估规范的摸索

7.高档学校博士学科点专项科研基金（20130091110050）: 微囊藻毒素经由过程下丘脑-垂体-睾丸轴下调雄性激素分化及排泄的机制研讨

8.江苏省天然科学基金（BK2011570）: 调控WNT旌旗灯号通路对特发性纤维化产生成长影响的研讨

9.江苏省天然科学基金（BK20151398）: Hedgehog-Wnt旌旗灯号通路到场特发性肺纤维化病发的份子机制切磋及疾病干涉干与的根本研讨

10.国度重点根本研讨成长打算“973”打算课题子名目（2010CB945103）: 卵巢早衰的份子机制及其初期展望、诊断生物标记的研讨

11.国度重点根本研讨成长打算“973”打算课题子名目（2007CB815603）: 微生物群落分化矿物的机理及其对生态环境的影响

获奖环境

2018年获南京大学“本科理论讲授优异指点教员”称呼。

2017年获“宝钢优异教员奖”称呼。

2010年获南京大学“我最爱好的教员”称呼。