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王 勇

文章来源:澳门十大正规平台网站 发布时候: 2017-12-24阅读次数: 6672

博士研讨生导师简介

姓名

王勇

研讨标的目的

疾病阐发,生殖: 多囊卵巢综合征及其活动干涉干与,溃疡性结肠炎,

接洽体例

澳门十大正规平台网站 科技馆215

德律风: 83594755Email: yongwang@doremond.com

学术兼职:

中国免疫学会毕生会员;中国剖解学会会员;江苏省剖解学会理事兼副秘书长;江苏省细胞学会生殖分会理事;江苏省植物学会会员;

小我简介

王勇,南京大学博士,南京大学根本医学传授,江苏省动商财产研讨院院长;江苏省医学份子技术重点尝试室PI兼秘书,性命阐发化学国度重点尝试室PI;讲授课程: 《一般人体布局学》、《构造学与胚胎学》、《构造学与胚胎学尝试》、《构造病理学》、《尝试免疫学》、《尝试植物学》、《构造病理》、《生殖生物学》、《人类生殖》等;科研标的目的为疾病阐发,生殖: 多囊卵巢综合征(PCOS)及其活动干涉干与,溃疡性结肠炎等;掌管多囊卵巢综合征相干国度天然科学基金6项,掌管横向课题8项,到场973、国度科技严重专项、国天然等7项;颁发文章100余篇,此中SCI论文50余篇。

代表性论文[5年通信作者和第一作者]

  1. Daojuan Wang,Yajing Weng,Yaling Zhang,Rong Wang,Tingyu Wang,Jianjun Zhou,Shanmei Shen,Hongwei Wang,Yong Wang. Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice. Sci Total Environ2020 Jul 22;745:141049.

  2. Daojuan Wang,Tingyu Wang,Rong Wang,Xinlin Zhang,Lei Wang,Zou Xiang,Lingjia Zhuang,Shanmei Shen,Hongwei Wang,Qian Gao,. Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis. J Transl Med2020 Feb 17;18(1):84.

  3. Qin Liu, Maomao Zhao, Wei Chen, Kaiyuan Xu, Fan Huang, Junxing Qu, Zhen Xu, Xiang Wang, Yong Wang, Yanan Zhua, Wenmei Wang, Mainstream cigarette smoke induces autophagy and promotes apoptosis in oral mucosal epithelial cells. Archives of Oral Biology, 111 (2020) 104646.

  4. Ya-nan Zhu, Yi-ting Zhang, Qin Liu, Shan-mei Shen, Xiang Zou, Yun-xia Cao, Wen-jun Wang, Long Yi, Qian Gao2, Wei-dong Yang1* and Yong Wang. Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women. BMC Medical Genetics (2020) 21:14.  https: //doi.org/10.1186/s12881-019-0945-1.

  5. Rong Wang, Yongzheng Luo, Yadong Lu, Daojuan Wang, Tingyu Wang, Wenyuan Pu, and Yong Wang. Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2. Oxid Med Cell Longev. 2019 Nov 15; 2019: 4703253. doi: 10.1155/2019/4703253.

  6. Wang R,Wang L,Luo Y,Wang D,Du R,Du J,Wang Y.Maggotproteinamelioratesdextransulphatesodium-inducedulcerativecolitisinmice. Biosci Rep.2018 Nov 28;38(6). pii: BSR20181799.

  7. Wang D,Wang W,Liang Q,He X,Xia Y,Shen S,Wang H,Gao Q,Wang Y.DHEA-inducedovarianhyperfibrosisismediatedby TGF-βsignalingpathway.JOvarianRes.2018 Jan 10;11(1):6. doi: 10.1186/s13048-017-0375-7.

  8. Chen XF, Wang L, Wu YZ, Song SY, Min HY, Yang Y, He X, Liang Q, Yi L, Wang Y, Gao Q. Effectofpuerarininpromotingfattyacidoxidationbyincreasingmitochondrialoxidativecapacityandbiogenesisinskeletalmuscleindiabeticrats.Nutr Diabetes.2018 Jan 12;8(1):1. doi: 10.1038/s41387-017-0009-6.

  9. Linghui Kong, Qien Wang, Jiewen Jin, Zou Xiang, Taoyu Chen, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. PLoS One. 2017 Nov 10;12(11):e0188029.

  10. Deng Z,Liu X,Jin J,Xu H,Gao Q,Wang Y,Zhao J. HistoneDeacetylaseInhibitorTrichostatinaPromotestheApoptosisofOsteosarcomaCellsthroughp53SignalingPathwayActivation.2016;12(11):1298-1308.

  11.  YANJIE XIA, WENQING WANG , LEI WANG , SHANMEI SHEN , YUNXIA CAO , LONG YI, QIAN GAO and YONG WANG, hOGG1 gene polymorphisms and susceptibility to polycystic ovary syndrome, BIOMEDICAL REPORTS 4: 421-426, 2016

  12.  Xiao Huang, Jiewen Jin, Shanmei Shen, Yanjie Xia, Pei Xu, Xiang Zou, Hongwei Wang, Long Yi, Yong Wang & Qian Gao (2015): Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line, Gynecological Endocrinology, 2016;32(3):201-5.

  13.  Yanjie Xia, Shanmei Shen , Xinlin Zhang, Zhantao Deng, Zou Xiang, Hongwei Wang, Long Yi, Qian Gao and Yong Wang, Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen, Reproduction, Fertility and Development2015 Mar 31. doi: 10.1071/RD14292.

  14. Qu J, Che Y, Xu P, Xia Y, Wu X and Wang Y. The higher response of vascular endothelial growth factor and angiotensin-II to human chorionic gonadotropin in women with polycystic ovary syndrome. Int J Fertil Steril 2015 8:373-8

  15. Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y, Wang W, Wu X, Wang H, Yi L, Gao Q and Wang Y. The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res 2015 Mar 22;8:11. doi: 10.1186/s13048-015-0139-1.

  16. Wang C, Gao C, Meng K, Qiao H and Wang Y. Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One 2015 Mar 6;10(3):e0119348.

  17. Zhang X, Zhang C, Shen S, Xia Yj, Yi L and Wang Y. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod 2013 28:3074-85.

承当科研名目[名目担任人]

掌管国度天然科学基金面上名目:

1基于TLR4/NF-κB/NETs通路研讨NLRP3介导高雄引诱卵泡发育妨碍的份子机制 ,81971346202001月至 202312

2发育期高雄激素介导卵巢细胞间去乙酰化酶差别抒发在PCOS病发中的机制研讨, 81771539, 2017-01-01~2020-12-31.

3p66shc调控PCOS卵巢纤维化病理的机理研讨, 81471422, 2014-01-01~2017-12-31.

4PCOS雄激素代谢相干基因的遗传(htSNPs)与表遗传(DNA甲基化)调控机制研讨,81170541,2011-01-01~2014-12-31.

5、胰岛素旌旗灯号体系相干基因多态性与PCOS表型的干系摸索,30672228,2007.1.1~2009.12.31.


获奖

2015年获评“本科生讲授优异”;

2016年获评“先生最爱好的教员”;

2017年获评“本科生讲授优异”;

2016年获评“研讨生招生进步前辈小我”;

2019年获评“优异博士生导师”奖;

2019年获评“南京大学魅力导师”奖;




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