澳门十大正规平台网站

姓   名

杨中州

接洽体例

电子邮件: zhongzhouyang@doremond.com

研讨标的目的

心脏发育与后天性心脏病

德律风: 83592264

尝试室网页

学术兼职

• 中国细胞生物学会常务理事，发育生物学分会会长

• 国度血汗管病专家委员会先芥蒂专业委员会常委

进修和任务简历

1997年于北京大学医学部取得医学硕士学位；1998年作为拜候学者在美国宾夕法尼亚大学任务进修；2004年于瑞士巴塞尔大学/弗里德里奇-米歇尔生物医学研讨所取得博士学位；2005年进入南京大学任务。

研讨标的目的

操纵小鼠模子，研讨心脏发育的调控机制及后天性心脏病的病发机理。

研讨标的目的包含:

1．心脏流出道发育

2．第他心场祖细胞发育

3．心肌发育，重塑与再生

科学题目

1．流出道发育进程中细胞转分解的调控机制。

2．细胞器互作及代谢调控心肌发育的机理。

代表性论文[通信作者]

1. 杨中州 心脏发育进程中的细胞运气改变与运气决议（创刊40周年数念专栏综述）.中国细胞生物学学报41卷第10期(2019年10月)。

2. Meng Xia, Wen Luo, Hengwei Jin and Zhongzhou Yang*. (2019) HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 146(13). pii: dev177477. (封面文章)

3. Hengwei Jin, Huijuan Wang, Jie Li, Shan Yu, Mingjie Xu, Zhiqian Qiu, Meng Xia, Jingai Zhu, Qiuting Feng, Jun Xie, Biao Xu and Zhongzhou Yang*. (2019)Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery. Developmental Biology 450: 82-89.

4. Han Hu, Mingyang Jiang, Yangpo Cao, Zhuojun Zhang, Bin Jiang, Feng Tian,Juan Feng, Yali Dou, Myriam Gorospe, Ming Zheng, Lemin Zheng,Zhongzhou Yang*, Wengong Wang*. (2019) HuR regulates phospholamban expression in isoproterenol-induced cardiac remodeling. Cardiovascular Research

5. Jisheng Hu, Yingchao Shi, Meng Xia, Zhongying Liu, Ruirui Zhang, Hongmei Luo, Tongcun Zhang, Zhongzhou Yang* and Baiyin Yuan*. (2018) WDR1-regulated actin dynamics is required for outflow tract and right ventricle development. Developmental Biology438:124-137.

6. Qi Xiao, Guoxin Zhang, Huijuan Wang, Lai Chen, Shuangshuang Lu, Dejing Pan, Geng Liu* and Zhongzhou Yang*. (2017) A p53 based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration. Development 144: 580-589.(Feature文章/封面文章)

7. Wen Luo, Xia Zhao, Hengwei Jin, Lichan Tao, Jingai Zhu, Huijuan Wang, Brian A. Hemmings and Zhongzhou Yang*. (2015) Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development. Development142, 732-742.

8. Junwei Nie, Mingyang Jiang, Xiaotian Zhang, Hao Tang, Hengwei Jin, Xinyi Huang, Baiyin Yuan, Chenxi Zhang, Janice Ching Lai, Yoshikuni Nagamine, Dejing Pan, Wengong Wang* and Zhongzhou Yang*. (2015) Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.Cell Reports13:723-732. (封面文章)

9. Xia Zhao, Shuangshuang Lu, Junwei Nie, Xiaoshan Hu, Wen Luo, Xiangqi Wu, Hailang Liu, Qiuting Feng, Zai Chang, Yaoqiu Liu, Yunshan Cao, Haixiang Sun, Xinli Li, Yali Hu, Zhongzhou Yang*. (2014) Phosphoinositide-dependent Kinase 1 and mTORC2 synergisticallymaintain postnatal heart growth and heart function in mice. Molecular and Cellular Biology 34 (11):1966-75. (spotlight/封面文章)

10. Baiyin Yuan,Ping Wan,Dandan Chu,Junwei Nie,Yunshan Cao,Wen Luo,Shuangshuang Lu,Jiong Chen* and Zhongzhou Yang*. (2014) A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice.American Journal of Pathology 184 (7):1967-80.

11. Qiuting Feng, Ruomin Di, Fang Tao, Zai Chang, Shuangshuang Lu, Wenjing Fan, Congjia   Shan, Xinli Li* and Zhongzhou Yang*. (2010) PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development. Molecular and Cellular Biology30: 3711-3721. (spotlight文章)

12. Zai Chang, Qin Zhang, Qiuting Feng, Jie Xu, Teng Teng, Qing Luan, Congjia Shan, Yali Hu, Brian A Hemmings, Xiang Gao and Zhongzhou Yang*. (2010) Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Developmental Biology 347: 384-391.

承当科研名目[名目担任人]

• 掌管在研名目: 1. 国度天然科学基金严重打算培养名目一项；2. 国度天然科学基金重点名目一项；3. 科技部“发育编程及其代谢调理”重点研发专项名目一项。

获奖环境

• 国度科技前进奖二等奖(2016, 排名第3)