澳门十大正规平台网站

朱敏生(形式所招生)

文章来源:澳门十大正规平台网站 发布时候: 2019-09-01阅读次数: 1179

研讨生导师简介

姓名

朱敏生

研讨标的目的:

胃肠心理与胃肠病学

接洽体例

zhums@doremond.com

学术兼职:

中国细胞生物学会理事

江苏省发育生物学会监事

小我简介

 1995年毕业于中国科学院上海生归天学研讨所,获理学博士学位。1999-2001年间在美国德州大学东北医学中间心理系处置博士后研讨,2004年至今在南京大学任传授。持久处置小鼠遗传学、光滑肌缩短心理学与疾病研讨。在体系生物学程度,研讨说明了光滑肌缩短钙机制、钙敏机制的份子根本;从光滑肌角度,体系说明了胃肠能源调理机制、肛门括约肌的自觉缩短机制、哮喘高反映性构成机制、瘦削性高血压构成机制等。在此根本上,展开光滑肌相干疾病(如胃肠病、哮喘、血管病、神经退行性病变等)的病发机制研讨和转化研讨。研讨功效别离颁发在 Gastroenterology20082013)、J. Biol. Chem.  (20102010201420142019)J Physiol (2014)Am J. Physiol (2011)Nature Med (2012)AJRCCM (2013)PNAS(2015)Nature Communications(2016)Genome Biol (2016)J Allegy Clin Immunol (2018)CMGH2019)等权势巨子杂志上。2016年获国度科技前进二等奖1项(第2)。


代表性论文[5年通信作者和第一作者]

  1. Li-sha Wei, Yan-Yan Zheng, Jie Sun, Pei Wang, Tao Tao, Yeqiong Li, Xin Chen, Yongjuan Sang, Danyang Chong, Wei Zhao, Yuwei Zhou, Ye Wang, Zhihui Jiang, Tiantian Qiu, Chao-Jun Li*, Min-Sheng Zhu*, Xuena Zhang* GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism. J Biol Chem 2020 in press.

  2. Chen X, Yun-Qian Gao, Yan-Yan Zheng, Wei Wang, Pei Wang, Juan Liang, Wei Zhao, Tao Tao, Jie Sun, Li-Sha Wei, Ye-Qiong Li, Yu-Wei Zhou, Zhen-Ji Gan, Xue-Na Zhang, Hua-Qun Chen, Min-Sheng Zhu* Intragenic MIR199A1 in the DNM2 gene contributes to the pathology of X-linked centronuclear myopathy. J Biol Chem 2020 in press.

  3. Sun J, Tao T, Zhao W, Wei LS, She F, Wang P, Li Y, Zheng Y, Chen X, Wang W, Qiao YN, Zhang XN, Zhu MS*. CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. J Genet Genomics 2019;46(3):109-118

  4. Tao T, Sun J, Peng YJ, Li Y, Wang P, Chen X, Zhao W, Zheng YY, Wei LS, Wang W, Zhou YW, Liu J, Shi YSZhu MS* Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. J Biol Chem 2019;294(28):10954-10968

  5. Pei Wang, Wei Zhao, Jie Sun, Tao Tao, Xin Chen, Yan-Yan Zheng, Cheng-Hai Zhang, Zhong Chen, Yun-Qian Gao, Fan She, Ye-Qiong Li, Li-Sha Wei, Ping Lu, Cai-Ping Chen, Ji Zhou, Da-Quan Wang, Liang Chen, Xiao-Hao Shi, Linhong Deng, Ronghua ZhuGe, Hua-Qun Chen, Min-Sheng Zhu*.Inflammatory Mediators Mediate Airway Smooth Muscle Contraction through a GPCR-TMEM16A-VDCC Axis and Contribute to Bronchial Hyperresponsiveness in Asthma. J Allergy Clin Immunol 2018;141(4):1259-1268

  6. Xu SCao S, Zou B, Yue Y, Gu C, Chen X, Wang P, Dong X, Xiang Z, Li K, Zhu MS*, Zhao QS*, Zhou GH* An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nucleaseGenome Biology 2016; 17:186-195

  7. Zhang CH, Wang P, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T,  Sun J, Peng YJ, Craige SM, Lifshitz LM, Jr KJF, Fogarty KE, ZhuGe R, Zhu MS* The molecular basis underlying the genesis of basal tone in internal anal sphincter. Nature Communication20167:11358.

  8. Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao X, Chen HQ and Zhu MS*. Regulation of DLK1 by the maternally expressed miR-379-544 cluster may underlie Callipyge polar overdominance inheritance. PNAS2015; 112(44):13627-32

  9. Chen, C.P., Chen, X., Qiao, Y.N., Wang, P., He, W. Q., Zhang, C.H., Zhao, W., Gao, Y.Q., Chen, C., Tao, T., Sun, J., Wang, Y., Gao, N., Kamm, K.E., Stull, J.T., and Zhu, M.S * Roles in vivo for Myosin Phosphatase Targeting Subunit-1 T694 and T852 Phosphorylation sites in Bladder Smooth Muscle. J. Physiology 2015;593(3):681-700



承当科研名目[名目担任人]

在研名目:

  1. 国度天然科学基金严重研讨打算(培养)课题, 非激活肌卫星细胞的体外扩增及其在肌肉朽迈防治中的能够性利用(2018-1-2021.12

  2. 国度天然科学基金面上名目,DNM2基因内miRNA在中心核肌病病变中的感化及其机制研讨316715482017.1-2020.12

  3. 国度天然科学基金面上名目苦物资及其受体T2R介导呼吸道光滑肌败坏的机制研讨320711212020-01-01- 2023-12-31


获奖环境

 2016年国度科技前进二等奖(第2实现人)暨教导部科技前进特等奖(第2实现人)一项基因工程小鼠等相干疾病模子研发与利用




返回澳门十大正规平台网站首页

澳门十大正规网站排行榜 澳门十大网上博网址 澳门正规十大博排名 澳门十大正规网站 澳门十大网上博网址 澳门十大正规网站排名 澳门网投十大信誉平台 澳门合法正规网投 澳门十大正规网站 手机网投登录