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姓名

王守宇

研讨标的目的:

肿瘤表观遗传

接洽体例

sywang@doremond.com

学术兼职:

• 江苏省环境诱变剂学会理事

• 中国抗癌学会会员

• 中国毒理学会会员

• 中国细胞生物学会会员

小我简介

王守宇，博士，传授，博士生导师。江苏省精采青年基金取得者，江苏省“333工程”培育工具，江苏高校“青蓝工程”中青年主干教员。最近几年来首要环绕环境致癌物的诱癌机制和肿瘤表观遗传睁开研讨，以第一或通信作者在Nature Cell Biology，Gut, The Journal of Clinical Investigation，Cell Research, Clinical Cancer Research，Nucleic Acids Research，Cancer Letters等杂志颁发多篇论文，掌管国度天然科学基金多项，以首要实现人获教导部高档学校天然科学奖二等奖（2013年）。

代表性论文[近5年通信作者和第一作者]

(1) Qiang Wang#, Chen Chen#, Qingqing Ding#, Yan Zhao, Zhangding Wang, Junjie Chen, Zerun Jiang, Yan Zhang, Guifang Xu, Jingjing Zhang, Jianwei Zhou, Beicheng Sun*, Xiaoping Zou*, Shouyu Wang*. METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020 Jul;69(7):1193-1205.

(2) Qiang Wang#, Wei Geng#, Huimin Guo#, Zhangding Wang, Kaiyue Xu, Chen Chen, Shouyu Wang*. Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer. J Hematol Oncol. 2020 May 19;13(1):57.

(3) Zhangding Wang#, Qiang Wang#, Guifang Xu#, Na Meng#, Xinli Huang, Zerun Jiang, Chen Chen, Yan Zhang, Junjie Chen, Aiping Li, Nan Li, Xiaoping Zou, Jianwei Zhou, Qingqing Ding*, Shouyu Wang*. The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells. RNA Biology. 2020 Jan 7:1-14.

(4) Qingsong Hu#, Chunlai Li#, Shouyu Wang#, Yajuan Li#, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin*, Liuqing Yang*, LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Research. 2019 Apr;29 (4):286-304.

(5) Jie Wu#, Zerun Jiang#, Chen Chen#, Qingsong Hu, Ziyi Fu, Junjie Chen, Zhangding Wang, Qiang Wang, Aiping Li, Jeffrey R. Marks, Changying Guo, Yun Chen, Jianwei Zhou, Liuqing Yang, Chunru Lin, Shouyu Wang*, CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. Cancer Letters. 2018 Aug 28;430:179-192.

(6) Danping Qiu#, Qiang Wang#, Zhangding Wang#, Junjie Chen, Donglin Yan, Yan Zhou, Aiping Li, Ruiwen Zhang, Shouyu Wang*, Jianwei Zhou*, RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2018 May;1864(5 Pt A):1552-1561.

(7) Shouyu Wang#, Ke Liang#, Qingsong Hu#, Jian Song, Yuedong Yang, Jun Yao, Selanere Mangala, Chunlai Li, Wenhao Yang, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Weiya Xia, Mien-Chie Hung, Jeffery R. Marks, Gary E. Gallick, Gabriel Lopez-Berestein, Elsa R. Flores, Anil K. Sood, Suyun Huang, Dihua Yu, Liuqing Yang*, Chunru Lin*, A JAK2-binding Long Noncoding RNA Promotes Breast Cancer Brain Metastasis. Journal of Clinical Investigation. 2017 Dec 1;127(12):4498-4515.

(8) Chunlai Li#, Shouyu Wang#, Zhen Xing, Aifu Lin, Ke Liang, Jian Song, Qingsong Hu, Jun Yao, Zhongyuan Chen, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Shuxing Zhang, Han Liang, Mien-Chie Hung, Gary E. Gallick, Leng Han, Chunru Lin* and Liuqing Yang*, A ROR1-HER3-lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis, Nature Cell Biology, 2017, 19(2):106-119.

(9)Qiang Wang, Jianping Xiong, Dianping Qiu, Xue Zhao, Donglin Yan, Wenxia Xu,Zhangding Wang, Qi Chen, Sapna Panday, Aiping Li, Shouyu Wang*, Jianwei Zhou*.Inhibition of PARP1 activity enhances chemotherapeutic efficiency in cisplatin-resistant gastric cancer cells. Int J Biochem Cell Biol. 2017 Nov;92:164-172.

承当科研名目[名目担任人]

• 国度天然科学基金面上名目（No. 81773383），长链非编码RNA经由过程JAK2调控环境身分引诱胃上皮细胞恶性转化的感化机制，2018/01-2021/12

• 国度天然科学基金面上名目（No. 81370078），miR-28-TXNL1-XRCC1 轴在顺铂引诱胃癌细胞凋亡中的感化及份子机制，2014/01-2017/12

• 江苏省精采青年基金（No. BK20170047），环境致癌物引诱胃癌产生的感化机制及干涉干与研讨，2017/06-2020/12

获奖环境

教导部高档学校天然科学奖二等奖 (2013，排名第2)