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侯亚义(生科院招生)

文章来源:澳门十大正规平台网站 发布时候: 2016-07-03阅读次数: 11098

 

博士研讨生导师简介

姓名

侯亚义

研讨标的目的:

细胞与份子免疫

干细胞与构造再生

接洽体例

德律风: 025-83686441

Email:yayihou@doremond.com

学术兼职: 江苏省免疫学会常务理事

小我简介

renwujianli: aomenshidazhengguipingtaiwangzhan mianyixuechangshishichuanshou/bodao。bieliyu1982he1987nianqudenanjingdaxuelixuexueshiheshuoshixuewei,1998nianribendongjingdaxueboshixuewei。cengzaidongjingdaxuechuzhiboshihouyantaohezuoweibaihouchuanshouzaimeiguomixigendaxueaomenshidazhengguipingtaiwangzhan tingzhixiezuokeyan。

keyanqingkuangjianjie: xianshouyaochuzhixibaoyufenzimianyixueyantao。jiyutlrjingqidenghaoluzi,mosuolelihuajishengwufenzigansheganyuqiantixia,suiximianyixibaoyingxiangyanzhengweiqingkuangjinerzengjinzhongliu/benshenmianyibingfashengchengzhangdefenzijizhi;tixidiyantaolezhongqiyinzi(midkine,mk)daochangzhongliumianyitaoyijizhi,chenglilemkbaxiangyizhizhongliudefangshi;chenglilehuodejianchongzhiganxibao(mscs)dexinfangshi,chanfalemirnadiaolixibaodejizhi,faxianlemir-181akejingyouguochengtgf-βjingqidenghaotongluyingxiangmscsdezengzhijimianyidiaoligongxiao;tixidichanfalemianyixibaobaohanshutuzhuangxibao(dcs)zaibenshenmianyibingxingbiepianxiangzhongdejizhi。yantaogongxiaobanfayustem cells、arthristis & rheumatism、adv mater、eur j immunol、nat.rev.rheumatol、biochim biophys acta、mol cancer ther、sci rep、clin sci、cell death disjiclin scidengguojiwaikanwu。zhangguanhedaochangguoguodutianrankexuejijinweiyanzhongyantaodasuan、guodutianrankexuejijin、kejibu“yanzhongxinyaochuangzhi”kejiyanzhongzhuanxiangmingmu、guodukejiyanzhongzhuanxiangmingmu、jiangsushengweishengting“xingweigongcheng”jijinjijiangsushengkexuejishutinggaojishuyantao(yiyao)yanzhongmingmudeng。2007niandujiangsushengkejiqianjinjiangsandengjiang;2008nianjiangsusheng“liudarencaicenling”diwupigaotiaolirencai;2014niandujiangsushengkejiqianjinjiangyidengjiang。yibanfaguojiwailunwen210pian,cizhongscilunwen125pian。shouquanfaxianzhuanli2xiang。

yantaolequ: mianyidiaokonghezhongliumianyi。jieluneineizaishenfenzaibenshenmianyixingjibingfashengchengzhangzhongdiaokongmianyibianrenjiyingduidefenzijizhi;mosuozhongliuweiqingkuangduizhongliumianyitaoyideganhuajizhijiyanfazhongliuyizhidexinjishudeng。


 

代表性论文

  

1.           Dong G, You M, Fan H, Ding L, Sun L, Hou Y*. STS-1 promotes IFN-α induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells. Eur J Immunol. 2015 Aug;45(8):2377-88.

2.           Liu F, Fan H, Ren D, Dong G, Hu E, Ji J, Hou Y*. TLR9-induced miR-155 and Ets-1 decrease expression of CD1d on B cells in SLE. Eur J Immunol. 2015 Jul;45(7):1934-45.

3.           Song Y, Liu X, Yue H, Ji J, Dou H, Hou Y*. Anti-inflammatory effects of benzenediamine derivate FC-98 on sepsis injury in mice via suppression of JNK, NF-κB and IRF3 signaling pathways. Mol Immunol. 67(2 Pt B):183-92, 2015.

4.           Ding L,  Huang X, Dong G, Hu E, Chen S, Wang T, Hu Q, Ni Y, Hou Y*. Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal. Biochimica et Biophysica Acta 1852:2494–2503, 2015.

5.           Dong G, Fan H, Yang Y, Zhao G, You M, Wang T, Hou Y*. 17β-Estradiol enhances the activation of IFN-α signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKε. Biochim Biophys Acta. 1852(8):1585-1598, 2015.

6.           Zhao S, Chu Z, Blanco VM, Nie Y, Hou Y, Qi X. SapC-DOPS Nanovesicles as Targeted Therapy for Lung Cancer. Mol Cancer Ther. 14(2):491-8, 2015.

7.           Zhao G, Yan G, Cheng J, Zhou X, Fang T, Sun H, Hou Y*, Hu Y*. Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression. Sci Rep. 5:7647, 2015.

8.           Lv M, Xu Y, Tang R, Ren J, Shen S, Chen Y, Liu B, Hou Y*, Wang T*. miR141-CXCL1-CXCR2 Signaling-Induced Treg Recruitment Regulates Metastases and Survival of Non-Small Cell Lung Cancer. Mol Cancer Ther. 13(12):3152-62, 2014.

9.           Ding L, Li B, Zhao Y, Fu YF, Hu EL, Hu QG, Ni YH, Hou YY*. Serum CCL2 and CCL3 as potential biomarkers for the diagnosis of oral squamous cell carcinoma. Tumour Biol. 35(10):10539-46, 2014.

10.       Fan H, Liu F, Dong G, Ren D, Xu Y, Dou J, Wang T, Sun L, Hou Y*. Activation-induced necroptosis not apoptosis contributes to B cell lymphopenia in active systemic lupus erythematosus Running title: necroptosis contribute to B cell lymphopenia in SLE. Cell Death & Disease, 5:e1416, 2014.

11.       Gong W, Hu E, Dou H, Song Y, Yang L, Ji J, Li E, Tan R and Hou Y*. A novel 1,2-benzenediamine derivate FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse septic model. Br J Pharmacol. 171(21):4866-78 , 2014.

12.       Song Y, Dou H, Wang P, Zhao S, Wang T, Gong W, Zhao J, Li E, Tan R, Hou Y*.  A novel small-molecule compound diaporine A inhibits non-small cell lung cancer growth by regulating miR-99a/mTOR signaling. Cancer Biol Ther. 15(10):1423-30, 2014.

13.       Dou H, Song Y, Liu X, Yang L, Jiang N, Chen D, Li E, Tan R, Hou Y*. A Novel Benzenediamine Derivate Rescued Mice from Experimental Sepsis by Attenuating Pro-inflammatory Mediators via IRAK4. Am J Respir Cell Mol Biol. 51(2):191-200, 2014.

14.       Zhao X, Liu D, Gong W, Zhao G, Liu L, Yang L, Hou Y*. Poly(I:C) Improves MSCs Immune Function: The Toll-like Receptor 3 Ligand, Poly(I:C), Improves Immunosuppressive Function and Therapeutic Effect of Mesenchymal Stem Cells on Sepsis via Inhibiting miR-143. Stem Cells. 32(2): 521-33, 2014.

15.       Nie Y, Du L, Mou Y, Xu Z, Weng L, Du Y, Zhu Y, Hou Y*, Wang T*. Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation. BMC Cancer. 13:582, 2013.

16.       Li P, Guo W, Du L, Zhao J, Wang Y, Liu L, Hu Y, Hou Y*. microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells. Clin Sci (Lond). 124(1):27-40, 2013.

17.       Liu L, Wang Y, Fan H, Zhao X, Liu D, Hu Y, Kidd AR 3rd, Bao J, Hou Y*. MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells. Stem Cells. 30(8): 1756-70, 2012.

18.       Wang T, Lv M, Shen S, Zhou S, Wang P, Chen Y, Liu B, Yu L, Hou Y*. Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer. PLoS One. 7(8): e43268, 2012.

19.       Liu L, Zhao X, Li P, Zhao G, Wang Y, Hu Y, Hou Y*. A novel way to isolate MSCs from umbilical cords. Eur J Immunol. 42(8): 2190-3, 2012.

20.       Zhao S, Wang H, Nie Y, Mi Q, Chen X, Hou Y*. Midkine upregulates MICA/B expression in human gastric cancer cells and decreases natural killer cell cytotoxicity. Cancer Immunol Immunother. 61(10): 1745-53, 2012.


承当科研名目

国度天然科学基金帮助名目(31370899)。MSC经由过程miR-30a调控DCs发生IFN-α的机制研讨。2014.1-2017.12。掌管人
江苏省科技厅临床医学科技专项--新型临床诊疗技术攻关(BL2014069): 无细胞医治的新技术—MSC来源微囊泡的感化机制及其在子痫后期中的利用远景评价。2014.7-2017.6。掌管人
国度天然科学基金严重研讨打算名目(91542113)。 狼疮性肾炎肾脏中MDSCs的扩增、分解与功效的研讨。2016.1-2018.12。掌管人
国度天然科学基金帮助名目(31570909)。MSC经由过程lncRNA HULC调控B细胞自噬的机制研讨。2016.1-2019.12。掌管人
国度天然科学基金帮助名目(81572557)。Midkine及其调控的非编码RNA在卵巢癌干细胞“干性”保持中的感化机制研讨。2016.1-2019.12。履行人
南京大学“中心高校根基科研营业费”名目。干涉干与TLR旌旗灯号调控髓系细胞分解及其影响肺部恶性转化的机制研讨。掌管人







 

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