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李尔广

文章来源:澳门十大正规平台网站 发布时候: 2016-07-03浏览次数: 10315

博士钻研生导师简介

姓名

李尔广

钻研标的目的:

1)传染与免疫
2)份子药理学

接洽体例

德律风: (02583593193

Email: erguang(at)doremond.com

学术兼职:

中国微生物学会会员,中国免疫学会会员,美国微生物学会会员; Frontiers in Microbiology, Frontier in Immunology评委

小我简介

    李尔广,病原生物学传授,博士生导师,澳门十大正规平台网站 微生物与药学尝试室担任人。北京西医药大学中药专业学士,美国密西西比大学药学院生药学博士;前后在美国思科瑞普斯钻研所(Scripps Research Institute)处置博士后钻研,前任免疫学助理传授、课题担任人;2008 年回澳门十大正规平台网站 任务,担任医先生《病原生物学》讲授,开设重生钻研课和公选课程。
    钻研标的目的: 1)从化先生物学角度钻研内源性份子代谢与疾病的干系,包含核苷酸、脂类和氨基酸代谢与天然免疫应对,肿瘤产生、神经退变性疾病的干系和在医治中的感化;2)天然产品和分解化合物抗微生物、抗肿瘤活性挑选和评估,包含天然及分解功效化合物的细胞和植物模子挑选,小份子化合物感化机理靶点判定和机理钻研;3)病原体传染进程中的天然免疫应对机制,包含天然免疫辨认和逃逸的份子机理等。
    曾掌管美国国立卫生钻研院(NIH)腺病毒基因医治载体革新和沙眼衣原体细胞入侵机文科研课题、掌管中国天然科学基金课题2项,到场NIH和国度天然科学基金名目多项,获美国NIH Research Career Development Award,是国度基金委“药源份子及感化机制立异群体”成员。以通信作者和课题担任人在PNAS, PLoS Pathogens, J. Immunology, J. Virology, J. Bacteriology, Antiviral Research, FASEB J.等刊物上颁发钻研论文。
    小我喜好: 喜好美食,酷爱大海、喜好棒球;任务之余喜好跑步,浏览。
    接待有志从化学角度钻研生物学景象的硕士、博士同窗和博士后插手钻研团队。

代表性论文(更新至2016年10月

 

Ren K, Zhang W, Chen X, Ma Y, Dai Y, Fan Y, Hou YY, RX Tan*, and Erguang Li*. An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4. PLoS Pathogens 12(10): e1005950, 2016.

Ren K, Lv Y, Zhuo Y, Chen C. Shi H, Guo L, Yang G, Hou Y, Tan RX*, Erguang Li*. Suppression of IRG-1 improves immune lung injury after RSV infection by reducing ROS production. J Virol, 90, 7313-7322, 2016.

Hui Jiang, Hengfei Shi, Man Sun, Yafeng Wang, Qingzhou Meng, Panpan Guo, Yanlan Cao, Jiong Chen, Xiang Gao, Erguang Li*, and Jianghuai Liu*. PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol, 197:2880-90, 2016.

Hengfei Shi, Ke Ren, Baojie Lv, Wei Zhang, Ying Zhao, Ren Xiang Tan*, and Erguang Li*. Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice. Scientific Reports, 6, 35851, 2016.

Zhang W, Chen C, Shi H, Yang M, Liu Y, Ji P, Chen H, Tan RX, Erguang Li*, Curcumin is a biologically active copper chelator with antitumor activity. Phytomed, 23, 1-8, 2016.

Guo X, Liu T, Shi H, Hou Y, Tan RX and Erguang Li*. NLRC5 induction regulates MHC II expression during RSV infection of airway epithelial cells. J Virol. 89. 7636-45, 2015.

Chen CM, Zhang W, Shi H, Zhuo Y, Yang G, Zhang A, Hou Y, RX Tan, Erguang Li*. A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation. Eur J Pharmacol. 761, 298-308, 2015.

Qiao H, X Chen, L Xu, J Wang, G Zhao, Y Hou, HM Ge, RX Tan*, and Erguang Li*. Antitumor effect of naturally occurring oligomeric resveratrol derivatives. FASEB J. 27, 4561-4571 (2013)

Chen X, Wang C, Xu L, Chen X, Wang W, Yang G, Tan RX, Y Jin* and Erguang Li*. A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease, Evidence-Based Complementary and Alternative Medicine, ID504563 (doi: 10.1155/2013/504563) (2013)

Wang J, Chen X, Wang W, Zhang Y, Yang Z, Jin Y, Ge H.M, Erguang Li*, *Yang G. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease, J. Ethnopharmacology, 147, 114-121 (2013).

Guo XC, Li XY, Xu XY, Sun T, Yang G, Wu ZW, Erguang Li*. Identification of OASL d, a splice variant of human OASL, with antiviral activity. International Journal Biochemistry Cell Biology 44:1133-1138 (2012).

Chen X, Wang Z, Yang Z, Wang J, Tan RX and Erguang Li*. Houttuynia cordata blocks HSV-2 infection through inhibition of NF-kB activation. Antiviral Research 92:341-345 (2011).

Zhu, H.R., Z.Y. Wang, X.L. Zhu, X.X. Wu, Erguang Li*, and Y. Xu*. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology. 59:70-76 (2010).

Lad, S.P., G. Yang, D.A. Scott, T.-H. Chao, J.d.S. Correia, J.C. de la Torre, and Erguang Li*. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. Molecular Immunology. 45:2277-2287 (2008).

Lad, S.P., J. Li, J. da Silva Correia, Q. Pan, S. Gadwal, R.J. Ulevitch, and Erguang Li*. Cleavage of p65/RelA of the NF-κB pathway by Chlamydia. Proc Natl Acad Sci USA. 104:2933-2938 (2007).

Lad, S.P., G. Yang, D.A. Scott, G. Wang, P. Nair, J. Mathison, V.S. Reddy, and Erguang Li*. Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific Protease That Interferes with the NF-κB Pathway of Immune Response. Journal of Bacteriology. 189:6619-6625 (2007).

Li, J., S. Lad, G. Yang, Y. Luo, M. Iacobelli-Martinez, F.J. Primus, R.A. Reisfeld, and Erguang Li*. Adenovirus Fiber Shaft Contains a Trimerization Element That Supports Peptide Fusion for Targeted Gene Delivery. Journal of Virology. 80:12324-12331 (2006).

Lad SP, Fukuda EY, Li J, de la Maza LM and Erguang Li*. Up-regulation of the JAK/STAT1 signal pathway during Chlamydia trachomatis infection. Journal of Immunology. 174: 7186-93 (2005).

Fukuda EY, Lad SP, Mikolon DP, Iacobelli-Martinez M and Erguang Li*. Upregulation of Prostaglandin Biosynthesis Attributes to IL-8 Production During Chlamydia Trachomatis Infection of Cervical Epithelial Cells. Infection and Immunity. 73:4017-24 (2005).

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