澳门十大正规平台网站

姓名

吴稚伟

研讨标的目的:

细胞与份子免疫，份子药理学

接洽体例

德律风: 025-8368-6092

Email: wzhw@doremond.com

学术兼职:

1.      Member, MPTi Steering Committee, CAMI/USAID/NIH, USA.

2.      Member, Association of Pacific Rim Universities (APRU), World Institute Public Health Steering Committee.

3.      教导部学位委员会

4.      南京大学科协 成员

小我简介

1.    任务简历

2005 - 此刻, 传授。 澳门十大正规平台网站 大众安康医学中间

2008 – 此刻，传授，副主任，南京大学性命阐发化学国度重点尝试室

2006 - 此刻，兼职研讨员。英国南汉普顿大学社会和统计研讨院

2007 – 此刻，兼职副传授，纽约大学澳门十大正规平台网站 ，美国

2000－2005，  研讨员， Leon levy 牙科研讨中间，宾夕法尼亚大学牙澳门十大正规平台网站

1997-2000，助理传授，生物医学研讨中间，洛克菲勒大学，美国；

2.    科研环境简介

（1）HIV-1的性传布份子(Sexual transmission)机理的研讨

（2）HIV膜卵白V1/V2, V3亚基(Domain)的布局及免疫原性的研讨和抗爱滋疫苗开辟

（3）杀微生物剂在防备艾滋病性传布的利用根本研讨

（4）引诱广谱中和抗体的基序疫苗（针对HIV、HPV、HSV、IFV和HCV等病毒）

（5）病毒沾染和细胞彼此感化及抗病毒份子机理研讨

上述课题接管/曾接管国度自然基金、沾抱病严重专项、973及美国USAID、英国DEFID和法国BioMerieux的经费撑持。

3.          研讨乐趣

（1） 人体对艾滋病毒沾染的抗体免疫反映和病毒免疫逃逸的份子机制，自然免疫在按捺病毒沾染的感化，疫苗研讨

（2） 病毒-细胞彼此感化的份子机理，病毒性病原体黏膜沾染的生物学及黏膜免疫

（3）病毒侵入机制、抗病毒药物研讨和杀微生物剂（ Topical Microbicides）的研发

代表性论文

1.      Min Qiu, Qin Wang, Ying Chu, Zhongping Yuan, Hongyong Song, Zhiwei Chen, and Zhiwei Wu*. (2012) Lignosulfonic Acid Exhibits Broadly Anti-HIV-1 Activity – Potential as a Microbicide Candidate for the Prevention of HIV-1 Sexual Transmission. PLoS ONE 7(4): e35906. doi:10.1371/journal.pone.0035906.

2.      Zhongping Yuan, Xilin Wu, Chao Liu, Genxing Xu, and Zhiwei Wu*. Asymmetric siRNA: New strategy to improve specificity and reduce off-target gene expression. Human Gene Therapy. 2012; 23:521-532. doi: 10.1089hum.2011.145.

3.      Yuanxi Kang, Zhiwei Wu, Terrence C K Lau, Xiaofan Lu, Li Liu, Allen K L Cheung, Zhiwu Tan, Jenny Ng, Jianguo Liang, Haibo Wang, Saikam Li, Bojian Zheng, Ben Li, Li Chen, Zhiwei Chen. CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection, and a resistant variant. Journal of Biological Chemistry. 2012; 287(20):16499-509. DOI:10.1074/jbc.M112.354084.

4.      Qiu, M., Chen, Y., Song, S., Song, H., Chu, Y., Yuan, Z., Cheng, L., Zheng, D., Chen, Z., Wu, Z*. Poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both HIV-1 and HSV infections - potential as a dual functional microbicide, Antiviral Research (2012), 96 (2):138-147 doi:

5.      Pinter, A.; Wu, A. Z.; Neubert, T.; Burkhart, M. D.; Honnen, W. J. Conformational heterogeneity in V1/V2 domain affects the immunological properties of this region. Retrovirology. 2012 SEP 13;9 2 2.

6.      Min Qiu, Yu Chen, Lin Cheng, Yin Chu, Hong-Yong Song and Zhiwei Wu*. Pyrrolidine Dithiocarbamate Inhibits Herpes Simplex Virus 1 and 2 Replication, and Its Activity May Be Mediated through Dysregulation of the Ubiquitin-Proteasome System. Journal of Virology. August 2013 vol. 87 no. 15 8675-8686.

7.      D. Nutbeam, S. Padmadas, O. Maslovskaya, Z.W. Wu. A health promotion logic model to review progress in HIV prevention in China. Health Promotion International . June 9, 2013。

8.      Min Qiu, Yin Chu, Si-Wei Song, Jie Gao, Na Yang, Xiao-Hui Wang, Zhi-Wei Wu*. Zinc ionophores pyrithione inhibits herpes simplex virus type 1 and 2 replication through interfering proteasome function and NF-κB activation. Antiviral Research (2013), 100 (1): 44–53.

9.      Ying Chu, Jiahuang Li, Xiling Wu, Zichun Hua, and Zhiwei Wu*. Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340. J. Biomedical Sci. 2013, 20:44.

10.  Song Hongyong,Chu Ying,Zhang Hongwei, Wang Xiaohui, Zhang Tong, Qiu Min, Wu Hao, Wu Zhiwei*. Epitope specificity of cross-clade neutralizing sera from Chinese HIV-1 positive individuals. Scandinavian Journal of Immunology 2013, 78, 357–370.

11.  Nan Zheng, Yanping Guo, Sabu Padmadas, Baoxi Wang, Zhiwei Wu*. The increase of STI infections calls for simultaneous preventative intervention for more effectively containing HIV epidemics in China. British Journal of Obstetrics and Gynaecology (In press).

12.  Siwei Song, Min Qiu, Ying Chu, Deyan Chen, Xiaohui Wang, Airong Su, Zhiwei Wu*. Berberine inhibits herpes simplex virus replication through modulating NF-κB and JNK pathways. Antimicrobial Agents and Chemotherapy (In press).

13.  Xiaowen Lv , Min Qiu, Deyan Chen, Nan Zheng, Yu Jin, Zhiwei Wu*. Apigenin and its analog, lutelin, inhibit enterovirus 71 replicaiton with distinct antiviral mechanisms. Antiviral Research (In revision).

承当科研名目

1.   人类免疫缺点病毒生物学和免疫应对机制研讨 – 根本研讨严重专项（973）

2.   杀微生物剂在防备艾滋病性传布的利用根本研讨 - 十一五严重沾抱病专项

3.   抗HIV及病原微生物阻断药物的研讨与开辟 - 科技部国际协作

4.   新型杀微生物剂的临床前和临床研讨 - 十二五严重沾抱病专项

5.   优化引诱广谱中和抗体的HIV基序疫苗 - 十二五严重沾抱病专项

6.   Developing public health strategies to effectively tackle the spread of HIV/AIDS among the economic migrants of China - 英国文明协会/海内成长署(DEFID/BC)

7.   Design of an Innate Immune Component as a HIV-1 Entry Inhibitor - Merieux Research Grant

8.   Scientific, regulatory and public health aspects of microbicide research and development - 美国国际成长总署（USAID）