澳门十大正规平台网站

姓名

邢峥

研讨标的目的:

份子病毒和病毒免疫学

新现病毒性病原和节制

接洽体例

德律风: 137 0145 2002

Email: zxing@doremond.com

地点: 南京大学鼓楼校区科技馆213室

学术兼职:

《Scientific Reports》Member of Editorial Board
《PLoS One》  Academic Editor
《Frontier in Immunology》 Guest Editor

小我简介

1. 任务简历

2009-       南京大学 传授、博士生导师；院长助理（2014- ）
2005-2009   加州大学戴维斯分校 助理研讨员、名目科学家
1999-2004   美国宾夕法尼亚大学、加州大学伯克利分校  博士后
1993-1999   美国康乃尔大学 微生物和免疫学 博士
1990-1992   美国The Scripps Research Institute拜候学者
1987-1990   中国防备医学科学院病毒所 助理研讨员
1983-1986   中国医学科学院、中国防备医学科学院 病毒研讨所 研讨生
1978-1983   安徽医科大学 大众卫生学院 本科

2. 科研环境简介

邢峥尝试室研讨禽流感病毒、引发“蜱虫病”的新型布尼亚病毒和引发神经体系沾染及胎儿“小头症”的寨卡病毒的宿主反映调控、病毒免疫和份子致病机制；曾以第一或通信作者颁发于JEM、 EMBO J、 JVI、EID和JBC等闻名学术期刊。有关细胞凋亡按捺因子Survivin在淋巴细胞发育中感化的功效曾别离被Nature Immunology （News and Views）和Nature Immunology Reviews （News Highlight）等刊物专文批评、先容。有关2009年“甲流病毒”与季候性流感病毒存在多个激进、掩护性表位的发明，颁发于美国疾病节制中间出书的《新现沾抱病》（EID），有包含美国ABC NEWS、CBS NEWS、FOX NEWS、REUTERS、UPI及英文《中国日报》国际媒体等停止了报道。近期研讨集合在引发“蜱虫病”的新型布尼亚病毒致病机制方面，提出病毒非布局卵白NSs 按捺天然免疫；发明NSs 能够构成包涵体，并与在搅扰素引诱通路中其关键感化的TBK1/IKKe/IRF3 复合物彼此感化，并且能够将该复合物从包浆埋没至包涵体，致使搅扰素引诱削弱、病毒复制加强，从而提出“病毒卵白构成包涵体作为病毒免疫逃逸机制”的新实际。该论文被JVI 编辑部选为“亮点论文”，重点加以推介；并由因其在病原微生物研讨中的 “特别意思（Special Significance）”，保举选进Faculty of 1000 的F1000 Prime Report。

3. 研讨乐趣

病毒性疾病的免疫和份子致病机制

病毒和宿主细胞彼此感化

病毒沾染的天然免疫

新现病毒性病原

代表性论文

1.  Chunyang Wang, Xinhui Yuan, Lianfu Ji, Yu Jin, Carol J. Cardona, Zheng Xing*. 2017.Enterovirus 71 Suppresses Interferon Responses by Blocking JAK/STAT Signalingthrough Inducing Karyopherin-α1 Degradation.

Journal of Biological Chemistry292(24):10262-10274. doi: 10.1074/jbc.M116.745729

2.  Xue Li, Bingqian Qu, Ganlin He, Carol Cardona, Yongchun Sun, &Zheng Xing^*.

2017. Critical Role of HAX-1 in Promoting Avian Influenza Virus Replication in Lung Epithelial Cells. Mediators of Inflammation In press

3.  Fu JG, Shi C, Xu C, Lin Q, Zhang J, Yi QH, Zhang J, Bao CJ, Huo X, Zhu YF, AiJ_, &Zheng Xing^*_. 2017. Outbreaks of Acute Gastroenteritis Associated with a Re-emerging GII.P16-GII.2 Norovirus in the Spring of 2017 in Jiangsu, China.
PLoS One In press

4.  Li Z, Hu J, Cui L, Hong Y, Liu J, Li P, Guo X, Liu W, Wang X, Qi X, Wu B, Feng Z, Shen A, Liu X, Zhao H, Tan W, Zhou J, XingZ, Bao C. 2017.
Scientific Reports 7(1):6503. doi: 10.1038/s41598-017-06853-1.

5.  Sun Q, Qi X, Zhang Y, Wu X, Liang M, Li C, Li D, Cardona CJ, Xing Z*. 2016. Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs.

Journal of Biological Chemistry 291(31):16138-49. doi: 10.1074/jbc.M116.715599

6.  Li Z, Bao C, Hu J, Liu W, Wang X, Zhang L, Ji Z, Feng Z, Li L, Shen A, Liu X, Zhao H, Tan W, Zhou J, Qi X, Zhu Y, Tang F, Cardona CJ, Xing Z*. 2016.
PLoS Neglected Tropical Diseases 10(4):e0004574. doi: 10.1371/journal.pntd.0004574.

7. Wang C, Ji L, Yuan X, Jin Y, Cardona CJ, Xing Z*. 2016. Differential Regulation of TLR Signaling on the Induction of Antiviral Interferons in Human Intestinal Epithelial Cells Infected with Enterovirus 71.
PLoS One 11(3):e0152177. doi: 10.1371/journal.pone.0152177.

8. Wang CY, Zhou R, Zhang Z, Jin Y*, Cardona CJ, and Xing Z*. 2015.
Intrinsic Apoptosis and Proinflammatory Cytokines Regulated in Human Astrocytes Infected with Enterovirus 71.
Journal of General Virology 09 July, 2015 doi: 10.1099/jgv.0.000235

9. Zhao C, Gao LY, Wang CY, Liu B, Jin Y*, and Xing Z*.2015^. Structural Characterization andAntiviral activity of A Novel Heteropolysaccharide Isolated from Grifola frondosa against Enterovirus 71.
Carbohydrate PolymersDOI: 10.1016/j.carbpol.2015.12.005

10. Wang CY, Gao L, Jin Y, Cardona CJ, Xing Z*. 2015. Regulation of host responses and viral replication by the mitogen-activated protein kinases in intestinal epithelial cells infected with Enterovirus 71.
Virus Research 197:75-84. doi: 10.1016/j.virusres.2014.12.016.

11. Q Sun, C Jin, LL Zhu, MF Liang, C Li, CJ Cardona, D Li, Z Xing*. 2015.
Host Responses and Regulation by NFkB signaling in Human Liver Epithelial
Cells Infected with Severe Fever with Thrombocytopenia Syndrome Virus.
Scientific Reports 2015 Jul 2;5:11816. doi: 10.1038/srep11816.

12. Shen X, Sun W, Shi Y, Xing Z*, Su X*. 2015.Altered viral replication and cell responses by inserting microRNA recognition element into PB1 in pandemic influenza A virus (H1N1) 2009.
Mediators of Inflammation 2015:976575. doi: 10.1155/2015/976575.

13. Hagag I.T., Mansour S.M.G, Zhang Z.R., Ali A.H., Ismaiel E.M., Salama A.A.,
Cardona C.J., Collins J., and Xing Z*.  2015.Pathogenicity of Highly Pathogenic Avian Influenza Virus H5N1 in Naturally Infected Poultry in Egypt. PLoS One 10(5):e0120061. doi: 10.1371/journal.pone.0120061

14. Wu XD, Qi, X., Liang MF, Li C, Cardona, C.J. Li D and Xing Z*.  2014.  Roles of Viroplasm-like Structure Formed by NSs in Infection with Severe Fever withThrombocytopenia Syndrome (SFTS) Virus. FASEB Journal 28(6):2504-16.

15. Wu XD, Qi X, Qu B, Zhang Z, Liang M, Li C, Cardona CJ, Li D, Xing Z*. 2014. Evasion of antiviral immunity through sequestering TBK1/IKKe/IRF3 into viral inclusion bodies.Journal of Virology 88(6):3067-3076.

16. Xing Z* and Murtaugh M. 2014. Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA [letter]. Emerging Infectious Diseases 20(2):337-8.

17. Qu BQ, Qi X, Wu XD, Liang MF, Li C, Cardona CJ, Wu B, Wegner M, Li D,
Xing Z*. 2012. Suppression of Interferon and NFkB responses in macrophages infected with severe fever with thrombocytopenia syndrome (SFTS) virus.
Journal of Virology 86(16):8388-401.

18. Xing Z *, Schefers, J, Schwabenlander, M, Jiao, Y, Liang, MF, Li C, Goyal S, Cardona CJ, Li D, Collins J and Murtaugh MP. 2013. SFTSV-like Bunyavirus in farm and wild life animals in the United States. Emerging Infectious Diseases 19(9):1487-9.

19.Chi CZ, Sun QY, Zhang ZR, Li X, Li X, Jin Y, and Xing Z. * 2013. Host Immune Response to Enterovirus 71 in Human Intestinal Epithelial Cells.
Virus Researchdoi:pii: S0168-1702(13)00149-4.

20. Qi X, Cui L, Jiao Y, Pan Y, Li X, Zu R, Huo X, Wu B, Tang F, Song Y, Zhou M Wang H, Cardona CJ, Xing Z. 2013. Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011.
Archives of Virology158(1):39-53. doi: 10.1007/s00705-012-1423-7.

21. Gao W, Sun W, Qu B, Cardona CJ, Powell K, Wegner M, Shi Y, Xing Z*. 2012. Distinct Regulation of Host Responses by ERK and JNK MAP Kinases in Swine Macrophages Infected with Pandemic (H1N1). 2009. Influenza Virus.
PLoS One 2012;7(1):e30328.

22. Qu BQ, Li X, Gao W, Sun WQ, Jin Y, Cardona CJ, Xing Z*. 2011.
Human intestinal epithelial cells are susceptible to influenza virus subtype H9N2.
Virus Research 163(1):151-9.

23.Xing, Z*. R. Harper, J.D. Anunciacion, Z.Q. Yang, W.Gao, B.Qu, and C.J. Cardona. 2011.Host Immune and Apoptotic Responses to Low Pathogenic Avian Influenza Virus H9N2 in Human Tracheobronchial Epithelial Cells.
American Journal of Respiratory Cells & Molecular Biology, 44(1):24-33

24. Xing, Z*, C.J. Cardona, J.D. Anunciacion, S. Adams, N. Dao. 2010.Journal of General Virology, 91(Pt2):343-51

25. Xing Z* and Cardona CJ. 2009. Preexisting immunity in human populations to novel influenza A (H1N1) virus. Emerging Infectious Diseases 15(11):1847-9.

承当科研名目

国度天然科学基金面上名目(PI): 蜱传播尼亚病毒SFTSV非布局卵白NSs和脂质小滴彼此感化及其机制和功效的研讨（2016.1 – 2019.12）

科技部国度重点研发打算名目“主要新发突病发原体宿主顺应与毁伤机制研讨”课题四（PI）: 新发突病发毒致使脑炎等病症的机制研讨（2016.7 - 2019.6）